Konkurs na stanowisko typu post-doc w projekcie NCN
Name of the Department (Nazwa jednostki): Jagiellonian University Medical College, Department of Physicochemical Drug Analysis
Job title (Nazwa stanowiska): Postdoctoral researcher
Link to the Department’s website: https://farmacja.cm.uj.edu.pl/pl/jednostki/katedra-chemii-farmaceutycznej/zaklad-fizykochemicznej-analizy-leku/
Requirements (Wymagania):
- PhD. in organic chemistry, medicinal chemistry or similar (or expected to be awarded by May 2024)
Please note that the funding institution (National Science Centre) regulations apply: the degree must be obtained no earlier than 7 years before joining the project, but this may be extended by previous sick or rehabilitation leaves granted, a child care leave, in case of women by 18 months for every child born or adopted, whichever manner of accounting for career breaks is preferable. For details please refer to the following document: https://www.ncn.gov.pl/sites/default/files/pliki/koszty_edycja_33_en.pdf
- Proven, hands-on experience in the design and synthesis of molecules with biological activities, the additional advantage would be experience with kinses inibitiors
- Track record of scientific publications related to medicinal chemistry are highly desirable
- Very good English language skills (written and oral)
- Ability to work independently, in a team and in collaborative projects
- Passionate, ambitious, hardworking and motivated for scientific development
Description of Tasks (Opis zadań):
The Post-Doc position is a vital part of a project Multitarget approach to break the vicious circle of tau pathology and neuroinflammation in Alzheimer’s disease: development of dual inhibitors of GSK-3β and IKK-β kinases.
The project is an answer to the lack of effective treatment for Alzheimer’s disease (AD) and addresses a growing interest in the development of multifunctional ligands targeting the most relevant AD pathological processes. Recently, the search for disease-modifying therapies for AD has focused on tauopathy and neuroinflammation. GSK-3β is a kinase that is directly involved in these processes and its upregulation in AD leads to tau hyperphosphorylation resulting in dysfunction of axonal transport and increased inflammatory response. The inflammation process in neurons is mediated by NF-κB complex that plays a pivotal role in the immune response.
The successful candidate will be involved in:
- Design of new compounds with the required biological activities and physicochemical properties
- Designing and planning of synthetic routes
- Synthesis of compounds (determination of structure and purity using NMR and LCMS techniques)
- Data analysis (structure-activity and structure-physicochemical propoerties relationship)
- Preparation of manuscript drafts
- Promotion of results at seminars and conferences
- Supervision of junior members of the group
- Contribution to the efficient functioning of the lab including administrative and organizational tasks
Type of Funding (Typ konkursu): Sonata Bis 9 – NZ
Deadline for submitting applications (Termin składania podań): 20-05-2024 (godz. 23:59)
Form of submitting applications (Forma składania podań): send your application to anna.wieckowska@uj.edu.pl by 20th May 2024 (please put „PostDoc application” in the subject line). Based on applications, top candidates will be chosen for project interviews. These interviews will take place on 23rd May 2024.
Conditions of employment (Warunki zatrudnienia):
The conditions of employment
- Full-time, 9 months
- Gross salary of 120 000 PLN per year (ca. 6000 PLN/month after-tax), health and social security insurance are included
- Preferred starting date: June 2024
- Application deadline: 20-05-2024
Competition Results Deadline (Termin rozstrzygnięcia konkursu): 24-05-2024
Work start date (Data rozpoczęcia pracy): 06-2024
Additional information (Dodatkowe informacje):
Required documents
- CV (in English) documenting achievements, scientific degrees, publications, technical skills, research stays and other relevant experience
- Document confirming the scientific degree
- Cover letter (in English) documenting motivation and the most important scientific achievement
- Contact details of at least two potential referees, including one of your supervisors
- Declaration (signed scan)
- Information on the processing of personal data (signed scan)
For additional information, please contact me at anna.wieckowska@uj.edu.pl
