Nazwa jednostki: Uniwersytet Jagielloński Collegium Medicum, Zakład Fizykochemicznej Analizy Leku

Nazwa stanowiska: Postdoctoral researcher

Link do strony www jednostki: https://farmacja.cm.uj.edu.pl/pl/jednostki/katedra-chemii-farmaceutycznej/zaklad-fizykochemicznej-analizy-leku/

Wymagania:

Requirements

1. D. in organic chemistry, medicinal chemistry or similar (or expected to be awarded by October 2020)

Please note that the funding institution (National Science Centre) regulations apply: the degree must be obtained no earlier than 7 years before joining the project, but this may be extended by previous sick or rehabilitation leaves granted, a child care leave, in case of women by 18 months for every child born or adopted, whichever manner of accounting for career breaks is preferable. For details please refer to the following document: https://www.ncn.gov.pl/sites/default/files/pliki/koszty_edycja_33_en.pdf

2. Proven, hands-on experience in the design and synthesis of molecules with biological activities, additional advantage would be experience with kinses inibitiors
3. Track record of scientific publications related to medicinal chemistry are highly desirable
4. Very good English language skills (written and oral)
5. Ability to work independently, in a team and in collaborative projects
6. Passionate, ambitious, hardworking and motivated for scientific development

Opis zadań:

The Post-Doc position is a vital part of a project Multitarget approach to break the vicious circle of tau pathology and neuroinflammation in Alzheimer’s disease: development of dual inhibitors of GSK-3β and IKK-β kinases (total timespan 4 years, funding: nearly 2.5 milion PLN).

The project is an answer to the lack of effective treatment for Alzheimer’s disease (AD) and addresses a growing interest in the development of multifunctional ligands targeting the most relevant AD pathological processes. Recently, the search for disease-modifying therapies for AD has focused on tauopathy and neuroinflammation. GSK-3β is a kinase that is directly involved in these processes and its upregulation in AD leads to tau hyperphosphorylation resulting in dysfunction of axonal transport and increased inflammatory response. The inflammation process in neurons is mediated by NF-κB complex that plays a pivotal role in the immune response.

The successful candidate will be involved in:

• Design of new compounds with the required biological activities and physicochemical properties
• Designing and planning of synthetic routes
• Synthesis of compounds (determination of structure and purity using NMR and LCMS techniques)
• Data analysis (structure-activity and structure-physicochemical propoerties relationship)
• Preparation of manuscript drafts
• Promotion of results at seminars and conferences
• Supervision of junior members of the group
• Contribution to the efficient functioning of the lab including administrative and organizational tasks

Typ konkursu: Sonata Bis 9 – NZ

Termin składania podań: 20-09-2020 (godz. 23:59)

Forma składania podań: send your application to anna.wieckowska@uj.edu.pl (please put „PostDoc application” in the subject line). Based on applications, top candidates will be chosen for project interviews. These interviews will take place at the end of September 2020.

Warunki zatrudnienia:

The conditions of employment

• Full-time, up to 4 years (probatory period applies)
• Gross salary of 120 000 PLN per year (10000 PLN/month total), health and social security insurance are included
• Preferred starting date: October 2020 (negotiable)
• Application deadline: 20-09-2020

Termin rozstrzygnięcia konkursu: 25-09-2020

Data rozpoczęcia pracy: 01-10-2020

Dodatkowe informacje:

Required documents

1. CV (in English) documenting achievements, scientific degrees, publications, technical skills, research stays and other relevant experience
2. Document confirming the scientific degree
3. Cover letter (in English) documenting motivation and the most important scientific achievement
4. Contact details of at least two potential referees, including one of your supervisors
5. Information clause and consent to the processing of personal data
6. Statement of a person employed for the post-doc

For additional information, please contact at anna.wieckowska@uj.edu.pl